assess understanding of genome informed risk assessments, uptake of corresponsing recommendations for management of disease risk, and impact on clinical outcomes in a prospective cohort study ( RFA-HG-19-013, RFA-HG-19-014, RFA-HG-19-015).Īn ongoing challenge in genomic medicine is understanding how genomics contributes to a person’s risk of developing a disease.return results to 25,000 diverse participants, and.combine PRS results with family history and clinical covariates to develop genome informed risk assessments,.

calculate and validate polygenic risk scores (PRS) in diverse populations for 10 conditions,.

More specifically, the eMERGE Genomic Risk Assessment and Management Network aims to:

The Network is investigating whether genome informed risk assessments for select conditions can be generated reliably across diverse populations and help inform clinical decisions about the management of patients at risk of developing a disease. The Network is focused on understanding how best to validate and implement genome informed risk assessments, which are defined as a combination of genomic, family history, and clinical risk factors to estimate a patient’s risk of developing disease. The eMERGE Genomic Risk Assessment and Management Network (July 2020 - April 2025) includes ten clinical sites and a study coordinating center.

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